ORCID: https://orcid.org/0000-0002-6259-855X
Publications (Primary)
15. Kwon KW*, Choi HG*, Choi H-H, Choi E, Kim H, Kim H-J, Shin SJ. Immunogenicity and protective efficacy of RipA, a peptidoglycan hydrolase, against Mycobacterium tuberculosis Beijing outbreak strains. Vaccine 2024 Mar 19;42(8):1941-1952. (*co-first author). https://doi.org/10.1016/j.vaccine.2024.02.039
14. Kwon KW*, Choi HG*, Kim KS, Park SA, Kim HJ, Shin SJ. BCG-booster vaccination with HSP90-ESAT-6-HspX-RipA multivalent subunit vaccine confers durable protection against hypervirulent Mtb in mice. NPJ Vaccines 2024 Mar 8;9(1):55. (*co-first author). https://doi.org/10.1038/s41541-024-00847-7
13. Kwon KW*, Kang TG, Lee A, Jin SM, Lim YT, Shin SJ, Ha S-J. Protective efficacy and immunogenicity of Rv0351/Rv3628 subunit vaccine formulated in different adjuvants against Mycobacterium tuberculosis infection. Immune Network 2023 Apr;23(2):e16 (*co-first author). https://doi.org/10.4110/in.2023.23.e16
12. Lee JM, Park J, Reed SG, Coler RN, Hong JJ, Kim L-H, Lee W, Kwon KW*, Shin SJ. Vaccination inducing durable and robust antigen-specific Th1/Th17 immune responses contributes to prophylactic protection against Mycobacterium avium infection but is ineffective as an adjunct to antibiotic treatment in chronic disease. Virulence 2022 Dec;13(1):808-832 (*co-corresponding). https://doi.org/10.1080/21505594.2022.2068489
11. Kwon KW, Aceves-Sánchez MJ, Segura-Cerda CA, Choi E, Bielefeldt-Ohmann H, Shin SJ, Flores-Valdez MA. BCGΔBCG1419c increased memory CD8+ T cell-associated immunogenicity and mitigated pulmonary inflammation compared with BCG in a model of chronic tuberculosis. Scientific Reports 2022 Sep 22;12(1):15824. https://doi.org/10.1038/s41598-022-20017-w
10. Kim L-H, Kang SM, Whang J, Kwon KW*, Shin SJ. Novel antibacterial activity of febuxostat, an FDA-approved antigout drug against Mycobacterium tuberculosis infection. Antimicrobial Agents and Chemotherapy 2022 Sep 20;66(9):e0076222 (*co-corresponding). https://doi.org/10.1128/aac.00762-22
9. Kwon KW*, Kim L-H, Kang SM, Lee JM, Choi E, Park J, Hong JJ, Shin SJ. Host-directed anti-mycobacterial activity of colchicine, an anti-gout drug, via strengthened host innate resistance reinforced by the IL-1β/PGE2 axis. British Journal of Pharmacology 2022 Aug;179(15):3951-3969 (*co-first author). https://doi.org/10.1111/bph.15838
8. Kang TG, Kwon KW*, Kim KS, Lee I, Kim MJ, Ha S-J, Shin SJ. Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 pulmonary influx. Nature Communications 2022 Jun 7;13(1):3155 (*co-first author). https://doi.org/10.1038/s41467-022-30914-3
7. Choi HG, Kwon KW*, Choi S, Back YW, Park HS, Kang SM, Choi E, Shin SJ, Kim HJ. Antigen-Specific IFN-γ/IL-17-Co-Producing CD4 + T-Cells Are the Determinants for Protective Efficacy of Tuberculosis Subunit Vaccine. Vaccines (Basel) 2020 Jun 11;8(2):300 (*co-first author). https://doi.org/10.3390/vaccines8020300
6. Kwon KW, Lee A, Larsen SE, Baldwin SL, Coler RN, Reed SG, Cho SN, Ha SJ, Shin SJ. Long-term protective efficacy with a BCG-prime ID93/GLA-SE boost regimen against the hyper-virulent Mycobacterium tuberculosis strain K in a mouse model. Scientific Reports 2019 Oct 29;9(1):15560. https://doi.org/10.1038/s41598-019-52146-0
5. Choi HH, Kwon KW*, Han SJ, Kang SM, Choi E, Kim A, Cho SN, Shin SJ. PPE39 of the Mycobacterium tuberculosis Strain Beijing/K Induces Th1-cell Polarization Through Dendritic Cell Maturation. Journal of Cell Science 2019 Sep 132:jcs228700 (*co-first author). https://doi.org/10.1242/jcs.228700
4. Kwon KW*, Choi HH, Han SJ, Kim JS, Kim WS, Kim H, Kim LH, Kang SM, Park J, Shin SJ. Vaccine efficacy of a Mycobacterium tuberculosis Beijing-specific proline-glutamic acid (PE) antigen against highly virulent outbreak isolates. The FASEB Journal 2019 May;33(5):6483-6496 (*co-first author). https://doi.org/10.1096/fj.201802604R
3. Kim WS, Kim H, Kwon KW*, Cho SN, Shin SJ. Immunogenicity and Vaccine Potential of InsB, an ESAT-6-like Antigen Identified in the Highly Virulent Mycobacterium tuberculosis Beijing K Strain. Frontiers in Microbiology 2019 Feb 12;10:220 (*co-first author). https://doi.org/10.3389/fmicb.2019.00220
2. Kwon KW*, Kim SJ, Kim H, Kim WS, Kang SM, Choi E, Ha SJ, Yoon JH, Shin SJ. IL-15 Generates IFN-g-producing Cells Reciprocally Expressing Lymphoid-Myeloid Markers during Dendritic Cell differentiation. International Journal of Biological Sciences 2019 Jan 1;15(2):464-480 (*co-first author). https://doi.org/10.7150/ijbs.25743
1. Kwon KW*, Kim WS, Kim H, Han SJ, Hahn MY, Lee JS, Nam KT, Cho SN, Shin SJ. Novel vaccine potential of Rv3131, a DosR regulon-encoded putative nitroreductase, against hyper-virulent Mycobacterium tuberculosis strain K. Scientific Reports 2017 Mar 8;7:44151 (*co-first author). https://doi.org/10.1038/srep44151
Publications (Co-authors)
23. Choi E, Choi H-H, Kwon KW, Kim H, Ryu J-H, Hong JJ, Shin SJ. Permissive lung neutrophils facilitate tuberculosis immunopathogenesis in male phagocyte NADPH oxidase-deficient mice. PLoS Pathogens 2024 Aug 23;20(8):e1012500
22. Kim H, Song EJ, Choi E, Kwon KW, Park JH, Shin SJ. Adjunctive administration of parabiotic Lactobacillus sakei CVL-001 ameliorates drug-induced toxicity and pulmonary inflammation during antibiotic treatment for tuberculosis. International Immunopharmacology 2024 May 10:132:111937
21. Choi H-G, Kwon KW, Shin SJ. Importance of adjuvant selection in tuberculosis vaccine development: Exploring basic mechanisms and clinical implications. Vaccine X 2023 Oct 29:15:100400
20. Bak Y, Park SC, Shim D, Ha Y, Lee JM, Kim H, Kwon KW, Yoon J-H, Shin SJ. Exacerbation of Mycobacterium avium pulmonary infection by comorbid allergic asthma is associated with diminished mycobacterium-specific Th17 responses.
Virulence 2021 Dec;12(1):2546-2561
19. Park J, Kim H, Kwon KW, Choi HH, Kang SM, Hong JJ, Shin SJ. Toll-like receptor 4 signaling-mediated responses are critically engaged in optimal host protection against highly virulent Mycobacterium tuberculosis K infection. Virulence 2020 Dec;11(1):430-445
18. Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim C-H, Yoon J-H, Shin SJ. An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response. Allergy Asthma and Immunology Research 2020 May;12(3):537-555
17. Kim H, Kwon KW, Park J, Kang H, Lee Y, Sohn E-J, Hwang I, Eum S-Y, Shin SJ. Plant-Produced N-glycosylated Ag85A Exhibits Enhanced Vaccine Efficacy Against Mycobacterium tuberculosis HN878 Through Balanced Multifunctional Th1 T Cell Immunity. Vaccines (Basel) 2020 Apr 18;8(2):189
16. Levillain F, Kim H, Kwon KW, Clark S, Cia F, Malaga W, Lannai F, Brodin P, Gicquel B, Guilhot C, Bancroft GJ, Williams A, Shin SJ, Poquet Y, Neyrolles O. Preclinical Assessment of a New Live Attenuated Mycobacterium tuberculosis Beijing-based Vaccine for Tuburculosis. Vaccine 2020 Feb 38(6):1416-1423
15. Kim WS, Kim JS, Kim HM, Kwon KW, Eum SY, Shin SJ. Comparison of immunogenicity and vaccine efficacy between heat-shock proteins, HSP70 and GrpE, in the DnaK operon of Mycobacterium tuberculosis. Scientific Reports 2018 Sep 26;8(1):14411
14. Choi SY, Kwon KW, Kim H, Choi HH, Shin SJ. Vaccine potential of ESAT-6 protein fused with consensus CD4+ T-cell epitopes of PE/PPE proteins against highly pathogenic Mycobacterium tuberculosis strain HN878. Biochemical and Biophysical Research Communications 2018 Sep 18;503(4):2195-2201
13. Kim WS, Jung ID, Kim JS, Kim HM, Kwon KW, Park YM, Shin SJ. Mycobacterium tuberculosis GrpE, A Heat-Shock Stress Responsive Chaperone, Promotes Th1-Biased T Cell Immune Response via TLR4-Mediated Activation of Dendritic Cells. Frontiers in Cellular and Infection Microbiology 2018 Mar 27;8:95
12. Kim H, Kwon KW, Kim WS, Shin SJ. Virulence-dependent induction of interleukin-10-producing-tolerogenic dendritic cells by Mycobacterium tuberculosis impedes optimal T helper type 1 proliferation. Immunology 2017 Jun;151(2):177-190
11. Kim WS, Kim H, Kwon KW, Im SH, Lee BR, Ha SJ, Shin SJ. Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity. Oncotarget 2016 Jun 7;7(23):33765-82
10. Kim WS, Kim JS, Cha SB, Kim H, Kwon KW, Kim SJ, Han SJ, Choi SY, Cho SN, Park JH, Shin SJ. Mycobacterium tuberculosis Rv3628 drives Th1-type T cell immunity via TLR2-mediated activation of dendritic cells and displays vaccine potential against the hyper-virulent Beijing K strain. Oncotarget 2016 May 3;7(18):24962-82
9. Cha SB, Kim WS, Kim JS, Kim H, Kwon KW, Han SJ, Cho SN, Coler RN, Reed SG, Shin SJ. Pulmonary immunity and durable protection induced by the ID93/GLA-SE vaccine candidate against the hyper-virulent Korean Beijing Mycobacterium tuberculosis strain K. Vaccine 2016 Apr 27;34(19):2179-87
8. Kim JS, Cha SH, Kim WS, Han SJ, Cha SB, Kim HM, Kwon KW, Kim SJ, Choi HH, Lee J, Cho SN, Koh WJ, Park YM, Shin SJ. A Novel Therapeutic Approach Using Mesenchymal Stem Cells to Protect Against Mycobacterium abscessus. Stem Cells 2016 Jul;34(7):1957-70
7. Kim WS, Kim JS, Cha SB, Kim SJ, Kim H, Kwon KW, Han SJ, Choi SY, Shin SJ. Mycobacterium tuberculosis PE27 activates dendritic cells and contributes to Th1-polarized memory immune responses during in vivo infection. Immunobiology 2016 Mar;221(3):440-53
6. Kim WS, Kim JS, Cha SB, Han SJ, Kim H, Kwon KW, Kim SJ, Eum SY, Cho SN, Shin SJ. Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis. PLoS One 2015 Dec 16;10(12):e0145234
5. Cha SB, Kim WS, Kim JS, Kim H, Kwon KW, Han SJ, Eum SY, Cho SN, Shin SJ. Repeated Aerosolized-Boosting with Gamma-Irradiated Mycobacterium bovis BCG Confers Improved Pulmonary Protection against the Hypervirulent Mycobacterium tuberculosis Strain HN878 in Mice. PLoS One 2015 Oct 28;10(10):e0141577
4. Kim JS, Kim WS, Choi HH, Kim HM, Kwon KW, Han SJ, Cha SB, Cho SN, Koh WJ, Shin SJ. Mycobacterium tuberculosis MmsA, a novel immunostimulatory antigen, induces dendritic cell activation and promotes Th1 cell-type immune responses. Cellular Immunology 2015 Nov-Dec;298(1-2):115-25
3. Cha SB, Jeon BY, Kim WS, Kim JS, Kim HM, Kwon KW, Cho SN, Shin SJ, Koh WJ. Experimental Reactivation of Pulmonary Mycobacterium avium Complex Infection in a Modified Cornell-Like Murine Model. PLos One 2015 Sep 25;10(9):e0139251
2. Choi HG, Kim WS, Back YW, Kim H, Kwon KW, Kim JS, Shin SJ, Kim HJ. Mycobacterium tuberculosis RpfE promotes simultaneous Th1- and Th17-type T-cell immunity via TLR4-dependent maturation of dendritic cells. European Journal of Immunology 2015 Jul;45(7):1957-71
1. Kim JS, Kang MJ, Kim WS, Han SJ, Kim HM, Kim HW, Kwon KW, Kim SJ, Cha SB, Eum SY, Koh WJ, Cho SN, Park JH, Shin SJ. Essential engagement of Toll-like receptor 2 in initiation of early protective Th1 response against rough variants of Mycobacterium abscessus. Infection and Immunity 2015 Apr;83(4):1556-67