노화조절연구실

1. 연구주제

1. Roles of telomere attrition during the aging of human cells in terms of genome architecture
2. Analysis of exosomes (extracellular vesicles) and secretomes from senesced human cells
3. Regulation of NAFLD pathogenesis
4. Regulation of skin barrier genes in terms of gene expression and protein modulation
5. Genome architecture analyses of aged human cells and screening of anti-aging compounds
6. Disease models- muscle dystrophy, sarcopenia, skin barrier, rheumatoid arthritis, osteoarthritis, lymphatic edema, neurodegenerative diseases, and cancer

2. 실험기법

1. Molecular cloning and gene delivery
2. Mammalian cell culture and 3D cultivation
3. Genome editing- AAVS1 targeting and Cas9-based methods
4. Analysis of aging- TRAP, TRF, universal STELA, etc., for telomere biology
5. Droplet digital PCR
6. Chromosome configuration capture (all 3C-based methods)
7. Bioenergetic analysis- gene expression and real-time metabolic activity (Seahorse)

3. 임상분석

1. 경상국립대학교병원 인체자원은행 활용- 1,600,742종 인체유래 자원
2. 질환중심연구 및 인체유래자원활용연구를 포함하는 중개연구

4. 대학원생 지원

1. 전일제(fulltitme) 학생에게 전액 장학금 및 생활비 지원
2. 대학원생 연구장려금
3. 국내외 학술대회 참여
4. 국내외 연수지원

(석사: 150만원/월 이상, 박사: 180만원/월 이상 지원)