수의과대학 수의과대학

주요 연구내용

• 감염병 예방용 OMV (Outer Membrane Vesicle) 백신물질 연구개발
• 병원체의 virulence factors
• Microbes-Host interactions from One Health perspective

교수님소개

학력 사항

• 학사: 경상대학교 수의학과
• 석사: 경상대학교 대학원 수의학과
• 박사: 구엘프대학교 (Univ. of Guelph, Canada)

경력 사항

• 수의과학검역원 (1998~2003)
• 토론토대학교 의과대학 Post-Doc (2004~2006)
• 한국생명공학연구원 (2006~2014)

주요 연구 업적 (selected publications)

• Bae EH, Seo SH, Kim CU, Jang MS, Song MS, Lee TY, Jeong YJ, Lee MS, Park JH, Lee P, Kim YS, Kim SH, Kim DJ. Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages. J Innate Immun. 2019;11(4):316-329.
• Lee TY, Kim CU, Bae EH, Seo SH, Jeong DG, Yoon SW, Chang KT, Kim YS, Kim SH, Kim DJ. Outer membrane vesicles harboring modified lipid A moiety augment the efficacy of an influenza vaccine exhibiting reduced endotoxicity in a mouse model. Vaccine. 2017 Jan 23;35(4):586-595. doi: 10.1016/j.vaccine.2016.12.025.
• Shim SM, Song EJ, Song D, Lee TY, Kim DJ, Nam JH, Gwin Jeong D, Lee CK, Kim SH, Kim JK. Nontoxic outer membrane vesicles efficiently increase the efficacy of an influenza vaccine in mice and ferrets. Vaccine. 2017 Jun 27;35(30):3741-3748.
• Gujrati V, Kim S, Kim SH, Min JJ, Choy HE, Kim SC, Jon S. (2014). Bioengineered bacterial outer membrane vesicles as cell-specific drug-delivery vehicles for cancer therapy. ACS Nano 8(2):1525-37.
• Choi CW, Park EC, Yun SH, Lee SY, Lee YG, Hong Y, Park KR, Kim SH, Kim GH, Kim SI. (2014). Proteomic characterization of the outer membrane vesicle of Pseudomonas putida KT2440. J. Proteome Res. 13(10):4298-309.
• Choi KS, Kim SH, Kim ED, Lee SH, Han SJ, Yoon S, Chang KT, Seo KY. (2014) Protection from hemolytic uremic syndrome by eyedrop vaccination with modified enterohemorrhagic E. coli outer membrane vesicles. PLoS One 9(7):e100229.
• Lee BJ, Lee SH, Song MS, Pascua PN, Kwon HI, Park SJ, Kim EH, Decano A, Kim SM, Lim GJ, Kim DJ, Chang KT, Kim SH, Choi YK. (2013). Adjuvant efficacy of mOMV against avian influenza virus infection in mice. J. Microbiol. 51(5):682-8.
• Kim SH, Ryu SH, Lee SH, Lee YH, Lee SR, Huh JW, Kim SU, Kim E, Kim S, Jon S, Bishop RE, Chang KT. (2011). Instability of toxin A subunit of AB5 toxins in the bacterial periplasm caused by deficiency of their cognate B subunits. BBA-Biomembranes 1808(10):2359-65
• Lee DH, Kim SH, Kang W, Choi YS, Lee SH, Lee SR, You S, Lee HK, Chang KT, Shin EC. (2011). Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming. Vaccine 29(46):8293-301.
• Kim SH, Lee SR, Kim KS, Ko A, Kim E, Kim YH, Chang KT. (2010). Shiga toxin A subunit mutant of Escherichia coli O157:H7 releases outer membrane vesicles containing the B-pentameric complex. FEMS Immunol Med Microbiol. 58(3):412-20.
• Lee EY, Choi DY, Kim DK, Kim JW, Park JO, Kim S, Kim SH, Desiderio DM, Kim YK, Kim KP, Gho YS. (2009). Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. Proteomics 9(24):5425-36.
• Lee SR, Kim SH, Jeong KJ, Kim KS, Kim YH, Kim SJ, Kim E, Kim JW, Chang KT. (2009). Multi-immunogenic outer membrane vesicles derived from an MsbB-deficient Salmonella enterica serovar Typhimurium mutant. J Microbiol Biotechnol. 19(10):1271-9.
• Kim SH, Kim KS, Lee SR, Kim E, Kim MS, Lee EY, Gho YS, Kim JW, Bishop RE, Chang KT. (2009). Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles. Biochim Biophys Acta 1788(10):2150-9.
• Smith AE, Kim SH, Liu F, Jia W, Vinogradov E, Gyles CL, Bishop RE. (2008). PagP activation in the outer membrane triggers R3 core oligosaccharide truncation in the cytoplasm of Escherichia coli O157:H7. J Biol Chem. 283(7):4332-43.
• Lamarche MG, Kim SH, Crepin S, Mourez M, Bertrand N, Bishop RE, Dubreuil JD, Harel J. (2008). Modulation of hexa-acyl pyrophosphate lipid A population under Escherichia coli phosphate (Pho) regulon activation. J Bacteriol. 190(15):5256-64.
• Parreira VR, Liao JH, Kim SH, Gyles CL. (2008). A homolog of the O157 urease-encoding O island 48 is present in porcine O149:H10 enterotoxigenic Escherichia coli. Vet Res. 39(3):38. (PMID: 18316019)
• Clements A, Tull D, Jenney AW, Farn JL, Kim SH, Bishop RE, McPhee JB, Hancock RE, Hartland EL, Pearse MJ, Wijburg OL, Jackson DC, McConville MJ, Strugnell RA. (2007). Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides. J Biol Chem. 282(21):15569-77.
• Ravi M, Ngeleka M, Kim SH, Gyles C, Berthiaume F, Mourez M, Middleton D, Simko E. (2007). Contribution of AIDA-I to the pathogenicity of a porcine diarrheagenic Escherichia coli and to intestinal colonization through biofilm formation in pigs. Vet Microbiol. 120(3-4):308-19.
• Kim SH, Jia W, Parreira VR, Bishop RE, Gyles CL. (2006). Phosphoethanolamine substitution in the lipid A of Escherichia coli O157:H7 and its association with PmrC. Microbiology 152(3):657-66.
• Bishop RE, Kim SH, El Zoeiby A. (2005). Role of lipid A palmitoylation in bacterial pathogenesis. J Endotoxin Res. 11(3):174-80.
• Kim SH, Jia W, Bishop RE, Gyles C. (2004). An msbB homologue carried in plasmid pO157 encodes an acyltransferase involved in lipid A biosynthesis in Escherichia coli O157:H7. Infect Immun. 72(2):1174-80.